Conventional   &   Emerging   cardiovascular   research  areas : The proposed Research model

 

                The   proposed cardiovascular institute   shall  involve , various clinical and applied clinical research  to facilitate  and sustain a long term research and development  environment in the field of cardiovascular medicine .Special emphasis would be made

To make the research activities  relevant to the need of  our  population .

 

 

Future of clinical research in India/Tamil nadu

Many factors have fuelled the growth of Clinical Research in India.

·       There is a positive change in the business environment in India. There has been a move to bring in regulations regarding data protection and data exclusivity.

·       Infrastructure required for conducting clinical research is available. This includes connectivity with remote locations. It is possible to conduct meetings .training through audio-visual media.

·       Since cost of drug research and development is high, pharmaceutical companies worldwide are attempting to lessen the time and cost required to bring a new drug to the patient. A large number of Contract Research Organizations have established operations in India, further influencing the clinical research culture.

·       There is increased awareness regarding ICH–GCP (The International Conference on Harmonisation-Good Clinical Practice) guidelines for conduct of clinical research.

·       The availability of a large pool of scientifically trained, English speaking personnel.

 

 

In this scenario   there is great scope   for   clinical   research   with   combined   Government and  private initiatives. 

 

 

Potential for collaborative research

 

A. Inter departmental  and multidisciplinary research

B. Other Government  institutions & University

C. Satellite centre of Tamil nadu Dr.MGR Medical university  proposed

D. Private educational institution participation

E. Corporate Institutions & Industry  sponsorship and initiative

F. Permanent research benches of   premier   foreign   Institutions  

 

 

 

The   research model   will comprise of   following   themes

 

A. Epidemiological

 

B .Basic sciences

 

C. Clinical sciences

 

D. Drug /Device trials

 

D. Advanced research areas

 

 

ADVANCED RESEARCH

Research   linking basic and clinical sciences

Chennai having number of   universities with separate basic science departments it gives us a great opportunity to initiate studies in basic sciences.

                  Aims to  promote  integrated basic and clinical research program to study innovative and developing technologies for the diagnosis, prevention, and treatment of CVD. It promotes opportunities to translate promising scientific and technological advances from discovery through pre-clinical studies to clinical trials.

  • Diagnostics: proteomic, genomic, and other biomarker technologies and imaging modalities/agents to identify CVD and guide therapy.
  • Therapeutics: tissue, stem cell-, and gene-based/guided therapies; regenerative and reparative medicine; and devices for circulatory and cardiac support and repair.
  • Surgery: improved surgical and image-guided approaches and evidence-based clinical research to advance promising new cardiovascular therapies, technologies, and surgical practices into clinical use.

                 

Bioengineering  & Bioinformatics

                          With  increasing  presence of  engineering  institutions  it will be ideal to involve them in active clinical research   .The fields  which are likely to open up in the future would be   Bioinformatics, computational and systems biology,  bioengineering, nanotechnology,   materials research, and personalized medicine .

 

ATHEROTHROMBOSIS & CORONARY ARTERY DISEASE

To study the etiology, pathogenesis, prevention, diagnosis, and treatment of CAD and atherothrombosis

Atherothrombosis: initiation, progression, and regression of atherosclerotic lesions in coronary arteries and other arterial beds; lesion instability and thrombosis; risk factor mechanisms; interaction of lipid fractions and other systemic and humoral factors with the arterial wall; biomarker and imaging diagnostics to quantify atherosclerotic disease and its progression; vulnerable plaques and vulnerable patients; and diabetes, obesity, other metabolic disorders, and diet and exercise related to atherothrombosis.   

HEART FAILURE & ARRHYTHMIAS

To study normal cardiac function and pathogenesis to improve diagnosis, treatment, and prevention of heart failure and arrhythmias. It promotes opportunities to translate promising scientific and technological advances from discovery through preclinical studies to multisite and network clinical trials. Areas supported by the Branch include:

  • Heart Failure: devices and medical and cell-based therapies targeting heart failure, myocardial protection, and pathogenesis and treatment of heart failure and cardiomyopathies.
  • Arrhythmias: arrhythmogenesis, genetic and environmental bases of normal cardiac electrical activity and arrhythmias, etiology of rare and common arrhythmias, and sudden cardiac death.
  • Myocardial disorders , myocardial preconditioning, amelioration and prevention of myocardial stunning and hibernation, and protection from ischemic/reperfusion injury.

Other potential areas of research 

VASCULAR BIOLOGY & HYPERTENSION

To investigate vascular biology and the etiology, pathogenesis, prevention, diagnosis, and treatment of hypertension and vascular diseases. It promotes opportunities to translate promising scientific and technological advances from discovery through preclinical studies to networks and multisite clinical trials.

  • Vascular Biology: biology of the vascular wall; vascular biology (related to hypertension; cerebrovascular, renal, and peripheral vascular disease; aneurysms; and lymphatic diseases); development of arteries, veins, lymphatics, and microcirculation; and angiogenesis.
  • Vascular Medicine: cerebrovascular, renal, and peripheral vascular disease; and aneurysms.
  • Hypertension: blood pressure regulation including central, renal, and vascular control; and cerebrovascular disease resulting from high blood pressure.

 

 

Diseases   Specific to Indian population  need to be addressed

 

CAD : Indian Perspective

 

Rheumatic  heart diseases

 

Endomyocardial fibrosis

 

Pregnancy and heart disease

 

Non specific arterial  disorders

 

Miscellaneous disorders

 

 

Methodology -   Funding  -Infrastructure – Human resources  

 

Need  to be formulated